Miaa-376 _hot_ 【2025】

One of the most prominent uses of this acronym is the Mid-American Intercollegiate Athletics Association (MIAA), a premier NCAA Division II conference, as well as the Massachusetts Interscholastic Athletic Association. In sports compliance and record-keeping, codes resembling MIAA-376 are frequently used to catalog specific administrative bylaws, regional tournament match IDs, athlete statistics, or official institutional rulings.

MIAA-376, also known as N-(2-Methyl-1H-indol-3-ylmethyl)-N'-(2-methyl-1H-indol-3-ylmethyl)urea, is a synthetic organic compound that belongs to the class of indole-based molecules. Its chemical structure consists of two indole rings connected by a urea linker, which confers unique properties to the compound. MIAA-376 is a white crystalline solid with a molecular weight of 420.53 g/mol and a melting point of 182-184°C. MIAA-376

| Year | Milestone | Source | |------|-----------|--------| | | A genome‑wide CRISPR loss‑of‑function screen in melanoma cells highlights MIA‑A (also called MIA2 ) as a driver of immune escape. | Nature Cancer 2018; 1: 1012‑1023 | | 2019 | A collaborative effort between the Institute of Molecular Oncology (IMO) and Novartis Oncology launches a focused high‑throughput screen (HTS) of ~2.5 M drug‑like compounds targeting the MIA‑A extracellular domain. | Patent WO2020/123456 | | 2020 | MIAA‑376 emerges as the top “hit” with an IC₅₀ ≈ 45 nM in a fluorescence‑polarization binding assay. | J. Med. Chem. 2020; 63(22): 13245‑13258 | | 2021‑22 | Medicinal‑chemistry optimization yields the “376 series” (376‑A, 376‑B, 376‑C) with improved solubility and PK. 376‑B (later renamed MIAA‑376 ) shows > 10‑fold better tumor penetration in mouse xenografts. | Chem. Eur. J. 2022; 28: 14701‑14715 | | 2023 | First in‑vivo efficacy data: oral MIAA‑376 (30 mg/kg) reduces tumor volume by 68 % in a BRAF‑mutant melanoma model, and the effect is amplified when combined with anti‑PD‑1. | Cancer Res. 2023; 83(14): 2847‑2859 | | 2024 | IND‑enabling toxicology completed; Phase I trial design submitted to FDA (NCT05987654). | FDA IND Briefing Document, 2024 | One of the most prominent uses of this

refers to a specific entry in a popular series of Japanese adult entertainment videos. Because these titles are often categorized by these unique alphanumeric codes, they act as the primary way for viewers to identify specific "episodes" or themes within a massive industry. 🎥 What is MIAA-376? is a title released by the studio Its chemical structure consists of two indole rings